SEPSIS

SEVERE SEPSIS

SEPTIC SHOCK

An infection plus SIRSwith presence of 2 or more general inflammatory variables .

Sepsis is the culmination of complex interactions between an infecting micro-organism and the host immune, inflammatory and coagulation responses.

Sepsis with organ dysfunction.

Organ dysfunction occurs primarily when host responses to infection are inadequate or the host cannot contain the infection, often due to high burden of infection, superantigens, resistance to WBC function or antibiotic resistance.  Anaerobic metabolism and increased lactate may result.

Persistent tissue hypoperfusion with organ dysfunction despite adequate fluid resuscitation.

 Initial attempts to correct the relative hypovolemia fail (increased capacitance due to vasodilation)